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KMID : 1199120090330060485
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Korean Diabetes Journal
2009 Volume.33 No. 6 p.485 ~ p.493
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The Relationship Between Coronary Artery Calcification and Serum Apolipoprotein A-1 in Patients with Type 2 Diabetes
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Seo Hyun-Ae
Kim Bo-Wan
Moon Seong-Su
Jeon In-Sang
Lee Jung-Eun
Lee In-Kyu
Kim Jung-Guk
Choi Yeon-Kyung
Jeong Ji-Yun
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Abstract
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Background: The incidence of type 2 diabetes mellitus is increasing annually and patient mortality is high. Coronary artery calcification is a predictor of coronary artery disease. Cardiovascular events, which are the main cause of death in type 2 diabetes patients, may be preventable by addressing risk factors associated with coronary artery calcification. We examined the relationships between coronary artery calcification, lipid profiles, and apolipoprotein levels.
Methods: We calculated the coronary calcium scores (CCS) of 254 subjects with type 2 diabetes (113 males, 141 females) via multi-detector row computed tomography (MDCT). Height, body weight, blood pressure, HbA1c, c-peptide, lipid profile and apolipoprotein were assessed concurrently.
Results: In patients with type 2 diabetes, Agatston score and apolipoprotein A-1 were significantly negatively correlated in both males and females (males P = 0.015, females P = 0.021). The negative correlation between Agatston score and apolipoprotein A-1 was retained for the entire patient sample after adjustments for age and sex (P = 0.022). Stepwise multiple regression anaylses with the Agatston score as the dependent variable indicate that apolipoprotein A-1 is a independent predictor (β coefficient = -0.047, 95%CI = -0.072 ~ -0.021, P < 0.001) of coronary artery calcification.
Conclusion: The results of our study suggest that apolipoprotein A-1 is a useful independent indicator of coronary artery calcification.
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KEYWORD
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Apolipoproteins, Atherosclerosis, Cardiovascular diseases, Lipids, Type 2 diabetes mellitus
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